PhD with Volker Kasche within the Graduate School of TU Hamburg Harburg and University Hamburg. Post-doc with Lila Gierasch at the University of Massachusetts, Amherst, USA. Group Leader at MPI for Biochemistry, Martinsried. Tenure-track professor for Biochemistry at University of Potsdam and since 2014 full professor in Biochemistry and Molecular Biology at the University of Hamburg. 2016-18 Managing Director of Institute of Biochemistry and Molecular Biology. Prizes and awards: Heisenberg fellowship award; Lundbeck foundation, Denmark; Joliot professorship at ESPCI, Paris, France; Innovation award, MDI BioLab, Maine, USA; Hamburg teaching award; Claussen-Simon-Stiftung award for Mentorship.
The ribosome is a central molecular machine that translates the genetic information into a corresponding polypeptide in an mRNA template-directed manner. Thereby, the mRNA is not a mere messenger for translation of codons into amino acids but bears additional layers of information for folding, solubility and expression level of the encoded protein. We use cell-wide approaches, including quantification of translational components, probing mRNA secondary structure, mRNA abundance and translation efficiency by means of deep sequencing to extract features that are selected to control translation and influence protein folding and function.